Research Article CODEN: IJPRNK ISSN: 2277-8713 Sharmita Gupta, IJPRBS, 2015; Volume 4(2): 291-304 IJPRBS

Some plants are known as medicinal because they contain active substances that cause certain reaction, from relenting to the cure of disease. Aloe vera Linn. and Azadirachta indica are most important and common medicinal plants. The synergistic effect from the combination of antibiotics with plant extracts against resistant bacteria leads to new ways for the treatment of infectious diseases. Synergistic effect of different parts of Aloe vera (Liliaceae) and Azadirachta indica (Meliaceae) were tested against pathogenic bacteria to evaluate the possibility of new pharmaceutical. In the present study the synergistic effect of antibiotics ampicillin and tetracyclin with methanolic leaf and stem extracts of Azadirachita indica and leaf extract of Aloe vera in combination were seen against bacteria E .coli. Many combinations were seen more effectiveness than expected individually. However many combinations did not exhibit any synergistic effect.